MLBPA Baseball offers an arcade-style take on America's national pastime with features designed to capture the nuances of the sport. These include snap throws, the double switch, bad hops and booted balls, rundowns, and outfielders hitting the cutoff man. The game also includes a full 162-game season mode with 28 professional caliber teams.

While MLBPA Baseball does not include a Major League Baseball license for real team names or logos, authentic players have been signed on with statistics and ratings based on the 1993 season. Features not found in the Super Nintendo version include digitized scoreboard scenes, a closer view behind the plate, and a continue option without the need for passwords.