In Beavis and Butt-Head Do U., the game plays as a point-and-click adventure game. The player directs Beavis and Butt-Head, who primarily wander around the campus of Highland State College during a class field trip, and aim to gather signatures from eight staff members in order to attend a party at the end of the day. Beavis and Butt-Head explore different locations, which each have unique conditions that can be utilized to complete their underlying goal. Sub-quests are made as they wander around and interact with the storyline. Items can be picked up, which can be found after interaction.

Beavis and Butt-Head head out with the class on a field trip to Highland State College. They're assigned to gather the signatures of eight staff members to prove they spent the day learning about the benefits of a Highland State education. Beavis and Butt-Head become self-motivated to explore the campus at their own pace, mesmerized about the idea of interacting with "college sluts".

Success will be rewarded by being allowed to attend a party at the end of the day.