Handkerchief is a 2D jump and run shooter video game developed by OPUS Corp. and published by Xsiv Games for Microsoft Windows in the year 2000. It is characterized by the conversion of enemy soldiers into troops, capturing machines for mobility and combined weaponry, unlocking pathways, strategically purchasing health refills and ammunition at in-stage vending machines, and multiple boss fights with distinct battle stages.

The game has 25 levels in its single-player mission mode, and is equipped with multiplayer mode.