Martian Gothic: Unification is a 2000 survival horror video game developed by Creative Reality for Microsoft Windows and Coyote Developments for the PlayStation and published by TalonSoft for Microsoft Windows and Take-Two Interactive for the PlayStation. It takes place on a Martian base in the year 2019, where a crew of three have been tasked to investigate 10 months of radio silence. They soon find that the crew members of the base have been killed, and now become re-animated bloodthirsty zombies.

Set in 2019, the megacorporation Earth Control has built the Vita-01 research station on Mars, located adjacent to Olympus Mons, and the first human settlement on the planet. The corridors and segments of the base are named after famous street names. The base was established following the discovery of ancient Martian bacteria, found within a meteorite in Antarctica. By the time of the game's main events, the Vita-01 base has been radio silent for ten months; the last transmission to Earth warns all future persons that come into contact with the base to "stay alone, stay alive."

The player assumes the roles of three characters sent to investigate Vita-01: American security officer Martin Karne; British bacteriologist Diane Matlock; and Japanese systems analyst Kenzo Uji. The two non-player characters are MOOD, a sentient artificial intelligence that manages the base, and medical officer John Farr (although often referred to as Ben Gunn), the deranged sole survivor of the base's initial crisis. Whilst deceased by the game's events, base director Judith Harroway is the most prominent voice featured in recovered audio recordings.